Iexplorer 4.0.12
Additionally, the rate of antimicrobial resistance among common Gram-positive IE pathogens has increased ( 5, 6), creating an urgent need for antibiotics with activity against such resistant pathogens. Recent studies indicate that the incidence of this serious infection is relatively high among life-threatening syndromes, ranging from 5.0 to 7.9 cases per 100.000 person-years ( 1– 4).
Infective endocarditis (IE) of left-sided cardiac valves is characterized by high morbidity and mortality. In conclusion, higher-dose daptomycin may be an effective and safe alternative to SOC in the treatment of left-sided IE due to common Gram-positive pathogens. Regimens with higher daptomycin doses were not associated with increased incidence of AEs. aureus (MRSA) bacteremia was 1.0 day, irrespective of daptomycin dose, representing a significantly faster bacteremia clearance compared to SOC (1.0 versus 5.0 days P < 0.01). In cohort A, median time to clearance of methicillin-resistant S. In-hospital and 6-month mortalities were similar in the two cohorts. Two-thirds of the patients treated with daptomycin had failed a previous antibiotic regimen. The median daptomycin dose was 9.2 mg/kg of body weight/day. Baseline comorbidities did not differ between the two cohorts, except for a significantly higher prevalence of diabetes and previous episodes of IE among patients treated with daptomycin. There were 29 and 149 patients included in cohort A and cohort B, respectively. Time to clearance of bacteremia, 6-month mortality, and adverse events (AEs) ascribable to daptomycin were also assessed. The primary outcome was in-hospital mortality. Among patients with left-sided IE due to Staphylococcus aureus, coagulase-negative staphylococci, and Enterococcus faecalis, we compared those treated with daptomycin (cohort A) to those treated with standard-of-care (SOC) antibiotics (cohort B). This was a prospective cohort study based on 1,112 cases from the International Collaboration on Endocarditis (ICE)-Plus database and the ICE-Daptomycin Substudy database from 2008 to 2010. The purpose of this study was to assess the influence of high-dose daptomycin on the outcome of left-sided IE due to Gram-positive pathogens. Learn more about the TAG.The use of daptomycin in Gram-positive left-sided infective endocarditis (IE) has significantly increased. TAG participants use their best judgment to find the best solutions for the Web, not just for any particular network, technology, vendor, or user. The Members of the TAG participate as individual contributors, not as representatives of their organizations. The mission of the TAG is to build consensus around principles of Web architecture and to interpret and clarify these principles when necessary, to resolve issues involving general Web architecture brought to the TAG, and to help coordinate cross-technology architecture developments inside and outside W3C. The TAG is a special group within the W3C, chartered under the W3C Process Document, with stewardship of the Web architecture. Many thanks for contributions to the TAG to the departing participant, Kenneth Rohde Christiansen (Intel Corporation), whose term ends at the end of January 2022. They join co-Chair Tim Berners-Lee and continuing participants, Daniel Appelquist (Samsung Electronics co-Chair), Hadley Beeman (W3C Invited Expert), Amy Guy (Digital Bazaar), Peter Linss (W3C Invited Expert co-Chair), Theresa O’Connor (Apple, Inc.) and Lea Verou (W3C Invited Expert) . The W3C Advisory Committee has elected the following people to the W3C Technical Architecture Group (TAG): Rossen Atanassov (Microsoft Corporation), Dapeng (Max) Liu (Alibaba Group) and Sangwhan Moon (Google). New in this level is § 2.5 Scoped Styles.ĬSS is a language for describing the rendering of structured documents (such as HTML and XML) on screen, on paper, etc. By way of cascading and inheritance, values are propagated for all properties on all elements.
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CSS Cascading and Inheritance Level 6: This CSS module describes how to collate style rules and assign values to all properties on all elements.It includes and extends the functionality of CSS Conditional 4, adding the generalized conditional rule and the chained conditional rule as well as introducing font processing queries to the supports query syntax used in rules. CSS Conditional Rules Module Level 5: This module contains the features of CSS for conditional processing of parts of style sheets, based on capabilities of the processor or the environment the style sheet is being applied in.This enables heavy optimizations by user agents when used well. CSS Containment Module Level 3: This CSS module describes the ‘contain’ property, which indicates that the element’s subtree is independent of the rest of the page.
The CSS Working Group has published the following three First Public Working Drafts: